NOVIDAT 250ML SUSP

Ciprofloxacin, a potent broad-spectrum antibiotic from the fluoroquinolone class, is widely utilized in treating diverse bacterial infections. Its effectiveness stems from a multi-step mechanism of action. First, it easily penetrates bacterial cell membranes, binding to receptors on DNA gyrase and topoisomerase IV enzymes crucial for cell wall synthesis and DNA replication. Next, Ciprofloxacin inhibits DNA gyrase, preventing the formation of the DNA cleavable complex, thereby impeding DNA replication and repair. Simultaneously, it inhibits topoisomerase IV, disrupting the relaxation of supercoiled DNA necessary for cell division. This dual inhibition prevents bacterial cell division and proliferation. As the bacterial cell persists in attempting division, it accumulates DNA damage, including single-stranded breaks, leading to cell death and the ultimate eradication of the infection. Ciprofloxacin demonstrates remarkable efficacy against gram-negative bacteria like Escherichia coli and Pseudomonas aeruginosa.