Desloratadine is a second generation tricyclic histamine receptor antagonist. It is an active descarboethoxy metabolite of loratadine. Desloratadine is a non-sedating, long-acting acting histamine antagonist with selective peripheral H1-receptor antagonist activity. Desloratadine after oral administration; selectively blocks peripheral histamine H1-receptors because it does not enter the central nervous system; that’s why it does not cause drowsiness.
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