Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin by selectively blocking the binding of angiotensin to the AT1, receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin synthesis. Amlodipine: Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions by binding to both dihydropyridine and nondihydropyridine sites into vascular smooth muscle and cardiac muscle.
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